EU-LIFE

Building and promoting Excellence in Life Sciences in Europe
Building and promoting Excellence in Life Sciences in Europe

Instituto Gulbenkian de Ciência

The Instituto Gulbenkian de Ciência (IGC) is an international life science research center in Portugal. Established by the Calouste Gulbenkian Foundation, the IGC's mission is to carry out biomedical research and training. The IGC acts as a host institution to international research groups, providing state-of-the-art research facilities in a stimulating and autonomous environment. The IGC runs several ambitious graduate training programs and a dedicated outreach and public engagement in science program.

Address
Rua da Quinta Grande, 6 P
2780-156 Oeiras
Portugal
People
Scientific Director
Instituto Gulbenkian de Ciência
Events
24 Nov 27 Nov 2015
Oeiras Portugal

Course description

The sequence of a genome alone does not carry enough information to fully understand how genomic processes are carried out in the cell nucleus; to achieve this, the knowledge of the three-dimensional (3D) architecture of a genome is necessary. Advances in genomic technologies and the development of new analytical methods, such as 3C-based methods, have allowed getting insights at unprecedented resolution into how the genome is organized. Recently, it has been shown that chromatin is organized in Topologically Associating Domains (TADs), large interaction domains that appear to be conserved among different cell types. In this course, participants will learn to use TADbit, a software for the analysis and modeling of Hi-C data.

The course will cover all the aspect of modeling with Hi-C data:
Generation of Hi-C contact matrices from raw data (that is, Hi-C specific quality check of the reads, mapping, filtering and normalization)
Analysis of Hi-C matrices (Hi-C map visualization, TAD identification, experiment comparison, and TAD selection)
3D modeling and analysis of TADs
The 3D module of TADbit is based on a computational module of the Integrative Modeling Platform (IMP, http://www.integrativemodeling.org) that uses chromosome conformation capture data to determine the 3D architecture of genomic domains and entire genomes at unprecedented resolutions.
Participants can bring-in specific biological questions and/or their on data to work on during the course.
At the end of the course, participants will be familiar with the TADbit software, enabling them to fully analyze and model Hi-C data.
Target Audience

The course is oriented to experimental researchers and bioinformaticians at the graduate and post-graduate levels. The last edition of this course was attended by people with different backgrounds and interested in the genome organization.
Moreover, Hi-C data have recently been used in metagenomics studies to accurately cluster metagenome assembly contigs into groups that contain nearly complete genomes of each species.
It is likely that the participants to this course aim at getting involved in generating Hi-C data for chromosome structure determination or that they just want to be able to correctly interpret and analyze publicly available data.

http://gtpb.igc.gulbenkian.pt/bicourses/CSDM15

IMPORTANT DATES for this Course:
Deadline for applications: November 15th 2015
Notification of acceptance within 72 hours of application (working days count)
Course date: November 24th to November 27th 2015

CSDM15 Course duration: 4 days CSDM15 Course Fee: Euro 360.00

19 Jul 1 Aug 2015
Oeiras Portugal

In the Summer School “Host-microbe symbioses – old friends and foes” we will explore stable host-microbe interactions as a spectrum from parasitic to mutualistic. It is becoming clear that most animals and plants associate with microbes during their life and that these greatly influence host biology. The course will last two weeks and will explore this field with leading scientists that bring a broad range of expertise and approaches.
The Summer School will be targeted at second or later years PhD students (from Europe).

28 Oct 2014
Oeiras Portugal

Our next Strategy Meeting, gathering Institute Directors and Working Group Chairs, will take place at the IGC in Oeiras, Portugal, on the 28th October 2014