Bioinformatician (Full-time or Part-time)
We wish to recruit a highly motivated Bioinformatician to participate in a project investigating epigenetic patterning in oocytes and how chromatin programmes gene expression states in the embryo. The project follows recent insights into the role of transcription in patterning epigenetic states in the oocyte, and the elucidation of mechanisms underlying atypical histone modification patterns in oocytes.
The project as a whole will focus on how chromatin states are established during oogenesis and their impact on transcriptional regulation. It will investigate the extent of and mechanisms underlying the persistence of oocyte-derived chromatin states in the embryo, and how this leads to imprinting in different developmental lineages. These questions will be investigated through a combination of approaches, including innovative, single-cell multi-omic and genome-wide analysis. Much of the work will be in mouse models, but we expect to explore parallels in human oocytes and embryos.
The successful applicant will join an interactive, multidisciplinary team in the Epigenetics Programme in the laboratory of Dr Gavin Kelsey. For more information on the work of the Kelsey’s group, please visit https://www.babraham.ac.uk/our-research/epigenetics/gavin-kelsey/.
The ideal candidate must have a PhD in Bioinformatics, computational biology, molecular biology or related discipline with strong Bioinformatics component. The post holder must have excellent working knowledge of epigenomic and transcriptomic analyses and relevant experience in programming in some of the main languages used in Bioinformatics.
The position would be suitable for an experienced Bioinformatics Researcher or for a Molecular or Developmental Biologist with experience in Bioinformatics, who welcomes the challenge of integrating genome-scale datasets to gain insight into epigenetic processes.
Funding for this position is available for up to 3 years in the first instance.
Please indicate on your application your preference for full-time (37 hours per week) or part-time hours (minimum of 22 hours per week).
Starting salary is £30,751 per annum to £34,166 per annum (FTE) depending on experience.
Full details of the position can be found here.
On applying please quote reference BIF-GK-MRC
Closing date for completed applications is Monday 20 August 2018.
NO AGENCIES PLEASE
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