EU-LIFE

Building and promoting Excellence in Life Sciences in Europe
Building and promoting Excellence in Life Sciences in Europe

ERC Funded Postdoc: Enhancer Control

Description

Job Description

The Laboratory of Computational Biology (Stein Aerts lab) at the VIB-KU Leuven Center for Brain and Disease Research, and the KU Leuven Center for Human Genetics, is seeking a highly motivated Postdoc to study enhancer logic and to decipher genomic regulatory programs underlying dynamic cellular processes.

You will use a combination of high-throughput techniques, including RNA-seq, ChIP-seq ATAC-seq, and massively parallel enhancer-reporter assays (MPRA) to identify and characterize enhancers in animal genomes. These data will be used to train new “enhancer models” using machine learning approaches, to block enhancers using CRISPR-Cas9 techniques, and to synthesize enhancers with new functions. As model system, you will use dynamic state transitions of human cancer cells, in vitro and in vivo.

Profile

Profile
  • PhD in Life Sciences, Bio-Engineering, Biomedical Science, or similar 
  • Strong experience or interest in gene regulation
  • Strong molecular biology and genetics skills, including cloning (Gateway/Infusion, BAC) and CRISPR-Cas9 
  • Experience with cell culture, mouse or Drosophila genetics is a plus
  • Experience with next-generation sequencing, transcriptomics, epigenomics, and bioinformatics is also considered as a plus. 
  • Fluency in written and spoken English is required.

We offer

  • A stimulating international research environment
  • A renewable contract 
  • Competitive salary and benefits
  • Relocation support possible for international applicants

How to apply?

How to Apply

​Motivated candidates are asked to apply online before 31 March 2017.

Additional requirements: Please submit a full CV and motivation letter. The coordinates of at least 2 references should be mentioned.

For additional information concerning this job please contact Prof Stein Aerts

 

Host Institute