ERC Funded Postdoc: Enhancer Control
The Laboratory of Computational Biology (Stein Aerts lab) at the VIB-KU Leuven Center for Brain and Disease Research, and the KU Leuven Center for Human Genetics, is seeking a highly motivated Postdoc to study enhancer logic and to decipher genomic regulatory programs underlying dynamic cellular processes.
You will use a combination of high-throughput techniques, including RNA-seq, ChIP-seq ATAC-seq, and massively parallel enhancer-reporter assays (MPRA) to identify and characterize enhancers in animal genomes. These data will be used to train new “enhancer models” using machine learning approaches, to block enhancers using CRISPR-Cas9 techniques, and to synthesize enhancers with new functions. As model system, you will use dynamic state transitions of human cancer cells, in vitro and in vivo.
- PhD in Life Sciences, Bio-Engineering, Biomedical Science, or similar
- Strong experience or interest in gene regulation
- Strong molecular biology and genetics skills, including cloning (Gateway/Infusion, BAC) and CRISPR-Cas9
- Experience with cell culture, mouse or Drosophila genetics is a plus
- Experience with next-generation sequencing, transcriptomics, epigenomics, and bioinformatics is also considered as a plus.
- Fluency in written and spoken English is required.
- A stimulating international research environment
- A renewable contract
- Competitive salary and benefits
- Relocation support possible for international applicants
How to apply?
Motivated candidates are asked to apply online before 31 March 2017.
Additional requirements: Please submit a full CV and motivation letter. The coordinates of at least 2 references should be mentioned.
For additional information concerning this job please contact Prof Stein Aerts