EU-LIFE

Building and promoting Excellence in Life Sciences in Europe
Building and promoting Excellence in Life Sciences in Europe

PhD Positions – Structural Biology Programme

Description

Structural Biology Programme integrates information on the structure of biologically important macromolecules – proteins, nucleic acids and their complexes. Progressive high-resolution methods of structural analysis such as X-ray diffraction, nuclear magnetic resonance, cryo-electron microscopy and tomography are used in combination with modern methods of molecular modelling, theoretical chemistry, and bioinformatics.

Open PhD Positions: 

Topic  Supervisor
1. A structural basis for the cross-talk between histones and RNA Polymerase II Richard Štefl
2. Atomic resolution study of transient structures and complexes of Microtubule Associated Protein 2c Lukáš Žídek
3. Behavior of alternative DNA structures at electrically charged surfaces Miroslav Fojta
4. Cracking the CTD code Richard Štefl
5. Cryo-electron microscopy analysis of influenza A replication in vivo Pavel Plevka
6. Characterizing sequence-structure-function relationships: A multi-dimensional approach for evaluating similarity in structural biology data Jaroslav Koča
7. Designing modified DNA fragments Radek Marek
8. Development and evaluation of next-generation drug design algorithms Konstantinos Tripsianes
9. Engineering the glycans of stem cells to have required bioactivity – a computational study combined with an experiment Jaroslav Koča
10. Experimental and Theoretical Studies of the Origin of Life on the Earth Jiří Šponer
11. Impact of 14-3-3 protein on the formation of protein aggregates involved in neurodegenerative diseases Jozef Hritz
12. Influence of membrane properties on peptide conformations Robert Vácha
13. Multiscale Modeling of Nucleic Acids Jiří Šponer
14. Partial atomic charges – a clue to predict chemical and biological behaviour of biomacromolecules Jaroslav Koča
15. Protein sensitivity of membrane curvature Robert Vácha
16. Structural basis of function of receiver domains of plant hybrid histidine kinases Lukáš Žídek
17. Structural changes of the selected protein fibrils induced by phosphorylation and the interaction with 14-3-3 proteins Jozef Hritz
18. Structure, dynamics and interactions of subunits of RNA polymerase of Gram-positive bacteria Lukáš Žídek
19. Structure-functional study of proteins involved in host cell recognition Michaela Wimmerová
20. The Three Prime Untranslated Region (3'UTR) Peter Lukavsky

Requirements:

Successful candidate must hold the equivalent of a Czech Master's degree (Mgr., Ing., MSc.) in the same or similar study programmes from an institution of recognized standing (four or five year undergraduate degree).

Detailed information available at: http://ls-phd.ceitec.cz/

Conditions and contact:

Starting date: September 2018
Complete applications can be submitted: until 15 March 2018
To apply please contact Olga Křížová on phd@ceitec.muni.cz

Information about CEITEC PhD School

  • 4-year program
  • Above-standard funding
  • State-of-the-art Core Facilities
  • International and interdisciplinary environment
  • Wide range of topics from experiences supervisors
  • Coursework in your chosen field and soft skill courses (publishing, funding…)

Information about Brno and Czech Republic

  • #4 most popular city in the world for students according to topuniversities.com
  • #1 best city for expat support according to Financial Times
  • The capital of South Moravian Region and the second largest city in the Czech Republic with a population of almost 400,000 people
  • A city of universities with more than 86,000 students
  • City of Gregor Mendel, the founder of genetics
  • #6 safest country according to whitepaper on the future of Europe
  • EU, Schengen, NATO, OECD member

Information about Masaryk University

  • The second largest university in the Czech Republic, consisting of nine faculties
  • Extremely wide range of study possibilities
  • State-of-the-art equipment, cutting-edge technologies and international cooperation
  • A member of the Compostela Group and the Utrecht Network
Host Institute