Building and promoting Excellence in Life Sciences in Europe
Building and promoting Excellence in Life Sciences in Europe

PhD student Biostatistiek


Your function within the department

The Antoni van Leeuwenhoek is part of the Netherlands Cancer Institute, a Comprehensive Cancer Center which combines a dedicated cancer hospital and a cancer research institute in a single organization. The biometrics department serves as the medical data center of the institute and provides the infrastructure for clinical and fundamental research with bio-statistical support, centralized patient-data collection and documentation, data processing and coordinated administration and monitoring of clinical trials. The statisticians and data managers collaborate in clinical and research projects both within the institute and for national and international multicenter studies.

The Julius Center is a research institute of the University of Utrecht Medical Center and has been set up to assist researchers with the design, conduct, data management, analysis and reporting of medical research. This ranges from drug research, to diagnostic and prognostic test and biomarker research, to etiologic, bioinformatics, decision support and healthcare innovation research. The Julius Center hosts the principal investigator of the European Asterix project: Advances in Small Trials dEsign for Regulatory Innovation and eXcellence (
This Ph.D. project aims to improve the design and analysis of biomarker-driven cancer clinical trials. The increasing knowledge about biological features of tumours and the growing number of molecularly targeted therapeutic agents require innovative designs and methods for clinical trials. Characteristics of the new approaches are small populations and surrogate endpoints. Statistical efficiency may be gained by using methods which do not treat every combination of drug / mutation / cancer type as independent trials. Bayesian methods could be developed which would allow for information between the combinations to be shared, for example by allowing for a common functional form, shared parameters, or the joint estimation of endpoints. The Ph.D. student will work both at the biometrics department of the Antoni van Leeuwenhoek hospital and at the Julius Center of the University Medical Center of Utrecht. In addition to studying design and analysis of studies in oncology, the candidate will be engaged in statistical consultancy for clinicians and researchers.

Your profile

You should be an independent and highly motivated researcher with an MSc in for example mathematics, econometrics or psychology with quantitative techniques as specialization. Great affection with clinical research in cancer is required. Experience with statistical programs such as SAS and R is an advantage. You should be able to communicate and work with researchers from various clinical and technical fields.

Being able to present a certificate of good conduct is a condition for the appointment.

Your career opportunities and terms of employment

The position is available immediately. You will receive a temporary position for 4 years. The gross monthly salary is between € 2.612,- en € 3.217,- (scale OIO) based on a 36-hours working week. In addition, a fixed year-end bonus is part of the secondary conditions. The terms of employment are in accordance with the Trade association for healthcare (CAO ziekenhuizen).
Additional information
The student will work overall 3 days per week at the Antoni van Leeuwenhoek hospital and 2 days at the Julius Centre in Utrecht. The promotion will take place at the Medical Center of the University of Utrecht. In addition, there is a possibility to obtain a degree in clinical epidemioly.
For more information about this position, please contact Dr. H. van Tinteren, project leader, e-mail: or professor K.C.B. Roes

Please respond by using the apply button.

Applications must include:

  • a curriculum vitae with a transcript of courses and obtained grades during BSc and MSc;
  • a motivation for your application and a description of research interests춾
  • Review of applicants will begin immediately and will continue until the position is filled.


How to apply

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