Building and promoting Excellence in Life Sciences in Europe
Building and promoting Excellence in Life Sciences in Europe

PhD student Computational Biology


Your function within the department

The lab of Elzo de Wit is a recently started group with an interest in genome function and dynamics. We aim to strongly integrate wet-lab and computational biology. We use a multitude of genomics methods such as ChIPseq, ATAC-seq and Hi-C to study the interplay between nuclear organization, chromatin states and gene expression.

Project The human genome in every cell measures roughly 2 meters in length but has to fit in a nucleus that is only 5-10 micrometers in size. To accomplish this the genome is folded in a non-random manner. It is becoming increasingly clear that the folding of the genome critically influences gene expression both in healthy and diseased cellular states. My lab aims to better understand the interplay between the folding of the genome and gene expression processes. For this we use genomics methods such as Hi-C. We actively develop computational analysis methods to process these data and integrate them with other genomics datasets such as RNAseq and ChIPseq (Krijger et al. 2016). The project aims to answer fundamental questions about the interplay between genome organization and gene expression.

Your profile

We seek an ambitious PhD student with a strong affinity for computational biology and biological problem solving. Strong commitment, proven programming experience, and high motivation and enthusiasm to work together with experimentalists is required.

Your career opportunities and terms of employment

You will be employed for a period of at least four years, with a possibility for extension. For a PhD student the gross salary per month is € 2.567,- to € 3.162,- according to the PhD student scales of the NKI. The salary depends on previous experience. The terms of employment will be in accordance with the CAO Hospitals (Collective Labour Agreement for Hospitals).
For further information about the position please contact Dr. Elzo de Wit tel. +31 20 512 7864 or e-mail:
Acquisition for this vacancy is not appreciated.


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