Building and promoting Excellence in Life Sciences in Europe
Building and promoting Excellence in Life Sciences in Europe

PhD Student to Investigate Molecular Mechanisms underlying Alzheimer’s Disease


Job Description

The VIB-KU Leuven Center for Brain & Disease Research is seeking a highly motivated and enthusiastic PhD student to join the Laboratory of Research of Neurodegenerative Diseases to contribute to the investigation of the molecular mechanisms underlying Alzheimer’s disease in the team of Prof. Lucía Chávez-Gutiérrez.

Throughout the past few years, our research team has successfully investigated how mutations in the gamma secretase complex cause familial dementia. The aim of our research is to develop novel strategies and tools to target the pathogenic mechanisms underlying familial Alzheimer’s disease.

You will join a dynamic and committed research team, with an outstanding international reputation. You will work at a state-of-the-art laboratory in a stimulating international environment and acquire extensive experience in molecular biology, biochemistry, enzymology, pharmacology, nanobody technology, protein expression and purification, and more.

For additional information concerning this position, please contact Prof. Lucía Chávez-Gutiérrez.

Key references:

  • Veugelen S, Saito T, Saido TC, Chávez-Gutiérrez L and De Strooper B. Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds. Neuron. 2016 Apr 20;90(2):410-6. 
  • Szaruga M, Veugelen S, Benurwar M, Lismont S, Sepulveda-Falla D, Lleo A, Ryan S. N, Lashley T, Fox N, Murayama S, Gijsen H, De Strooper B and Chávez-Gutiérrez L. Qualitative changes in brain Aβ profiles form the basis of γ-secretase mediated neurodegeneration in familial Alzheimer disease.  J Exp Med. 2015 Nov 16; 212(12):2003-13. Featured article in J Exp Med. 
  • Elad N, De Strooper B, Lismont S, Hagen W, Veugelen S, Arimon M, Horré K, Berezovska O, Sachse C, and Chávez-Gutiérrez L. The dynamic conformational landscape of γ-secretase. J Cell Sci. 2015; Feb 1;128(3):589-98.


  • Applicants should hold a MSc degree in biochemistry, biomedical engineering, biomedical sciences, medicine, pharmacology or any related discipline.
  • The candidate should be creative, motivated and dedicated to conduct a challenging project in a highly competitive research field and be eligible for (inter)national funding.
  • Interest in the field of neurodegeneration. 
  • Motivated students of all nationalities with a strong commitment to basic and/or clinical research are invited to apply.
  • Ability to start your project as soon as possible (latest by September/November 2017).

We offer

We offer an exciting and challenging position in a dynamic research group for 1 year, with potential extension up to 4 years after positive evaluation.

How to apply?

How to Apply

​Please submit your application online. Additional required information: Please submit a full CV and motivation letter with your application.

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