Post-Doctoral Fellow Position for CellViewer
The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG shares principles of an interdisciplinary, motivated and creative scientific team that is supported by high-end and innovative technologies and a flexible and efficient administration.
CRG has been conferred with a badge of ‘HR Excellence in Research’ by the European Commission, in recognition to its progress in implementing the European Charter for Researchers and the Code of Conduct for Recruitment of Researchers, that among others consists of transparent, merit-based recruitment procedures and attractive work-life balance working conditions.
For further information: www.crg.eu
A unique opportunity is available for a candidate interested in working in a multidisciplinary environment applying advanced optical tools in biomedical research at the Center for Genomic Regulation (CRG)). The successful candidate will be expected to contribute to research in CellViewer FET open project, which is an H2020 European collaborative project. CellViewer (http://www.cellviewer.eu/) focuses on elucidating nuclear architecture and how it regulates nuclear function. The successful candidate will use novel optical tools such as single particle tracking and super-resolution microscopy to resolve the dynamics and sub-cellular localization of nuclear architectural proteins and transcriptional machinery in cells undergoing differentiation. The long-term goal would be to elucidate how molecular complexes coordinate their spatio-temporal organization to activate and repress genes during cell fate transitions. This project overall will give new insights into how cells determine their fate and therefore allow us to have better control over cell fate determination.
Maria Pia Cosma, PhD
Reprogramming and Regeneration
Center for Genomic Regulation (CRG)
Melike Lakadamyali, PhD
Perelman School of Medicine, Department of Physiology
University of Pennsylvania,
About the team/ lab
Pia Cosma’s group is focused on the study of the mechanisms that control somatic cell reprogramming and tissue regeneration, with a focus on dissecting out the function of the Wnt signaling pathway in these processes (http://piacosmalab.com/). Using super-resolution fluorescence microscopy (stochastic optical reconstruction microscopy; STORM) (Rust et al., Nature Methods, 2006) in collaboration with the group of Melike Lakadamyali (Institute of Photonic Sciences, Barcelona) we have dissected out the nanoscale organization of nucleosome assembly, with high molecular specificity and spatial resolution in a variety of somatic and stem/ reprogrammed cells. We have delineated a novel model of chromatin fiber assembly, and the relationship among the decoded structure and naïve pluripotency (Ricci et al. Cell 2015).
Who would we like to hire?
· You hold a Phd in Biophysics, Biology, Physics or related disciplines.
· You have experience and background in the fields of microscopy, in particular single molecule tracking, image processing and statistical analysis.
· You are fluent in English
Desirable but not required
· Positively evaluated will be experience with optical methods, computer programming (Matlab, Python and similar) and a strong background in biophysics.
· Duration: 2-3 years
· Estimated annual gross salary: A competitive salary will be provided, based on professional experience
· Starting date: the fellowship will start as soon as the candidate is hired
We offer work in a highly stimulating environment with state-of-the-art infrastructures, providing the successful applicant with unique professional career opportunities.
CRG offers and promotes a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, race, religion or sexual orientation.
The CRG is committed to reconcile a work and family life of its employees and within the work-life balance programme is offering an opportunity to benefit from annual leave allowance, flexible working hours and teleworking programme.
All applications must include:
1. A motivation letter addressed to Dr Cosma and Dr. Lakadamyali.
2. A full CV including contact details.
3. Two contacts for further references.
All applications must be addressed to Dr. Dr Pia Cosma and Dr. Lakadamyali and be submitted by means of on-line application on the official website of the CRG - http://recruitment.crg.eu/.
Application deadline: Applications will be regularly reviewed until position is filled.
CellViewer, FET open H2020 project (nº 686637)