Postdoc – RNA translation in cancer
Your function within the department
The Faller lab is seeking a talented and enthusiastic individual to investigate how alterations in RNA translation can affect the genesis and progression of cancer.
The project involves the study of RNA translation in models of colorectal cancer. Many mechanisms control the rate of mRNA translation in the intestine, including the availability of nutrients. This project will probe these mechanisms, using sophisticated in vivo models and state-of-the-art genomics technology. Our ultimate goal is to identify mechanisms through which we can regulate RNA translation in cancer, and to find novel strategies that can be exploited therapeutically to improve patient outcomes.
We are seeking a motivated Postdoc who has been awarded (or in the final stages of obtaining) a PhD in a field relevant to cancer biology or RNA translation. You will have published (or be about to publish) in a peer-reviewed journal, be able to communicate scientific ideas effectively and have a demonstrable capability for independent thinking. Experience with in vivo models and approaches such as polysome profiling are also desirable but not required.
The Netherlands Cancer Institute (NKI) is an independent research institute located in the lively city of Amsterdam. The Institute covers all major areas of molecular and cellular cancer biology, with special emphasis on mouse tumour models, functional screens, cancer cell biology and translational research. The Netherlands Cancer Institute and the Antoni van Leeuwenhoek Hospital form an integrated cancer centre, combining a research laboratory and a hospital under one roof in a single, independent organization. All hospital departments have an extensive research program, often in close collaboration with the research laboratory. This research is focused on improving cancer treatment through imaging and molecular diagnostics, new medicine, improved operating techniques, more effective radiotherapy, and combinations of these, epidemiology and psychosocial research.
State-of-the-art facilities The research groups at the NKI-AVL are supported by state-of-the-art equipment and facilities, most with dedicated support staff. The Institute has a large mouse facility with special units for transgenics, intervention studies, pathology and functional imaging, a genomics facility, a functional screening facility for RNAi and small-molecule libraries, excellent facilities for microscopy, flowcytometry, protein expression and purification, and many more.
Inspiring international atmosphere Approximately 550 people work in the research laboratory and many of the clinicians are involved in research. Work discussions, lectures and seminars are in English and a large number of non-Dutch post-docs, students and staff members contribute to the stimulating and international atmosphere of the Institute.
Your career opportunities and terms of employment
We offer a stimulating and interactive research environment, free use of all state-of-the-art facilities, a competitive salary (including possibilities for additional tax-reduction, a gross salary of € 3.097,- to € 3.774,- according to the FWG-function group 55 and depending on previous experience) and housing facilities in the vicinity of the Institute. Your temporary employment will be for a period of at least 3 years. The terms of employment will be in accordance with the CAO Ziekenhuizen (Collective Labour Agreement for Hospitals).
Information For further information visit our home page (https://www.nki.nl/divisions/molecular-genetics/faller-william-group/) or contact William Faller at tel. +31 20 5122018.
The closing date for applications is 02/06/17.