Building and promoting Excellence in Life Sciences in Europe
Building and promoting Excellence in Life Sciences in Europe

Postdoc Telomere and Genome Integrity


Your function within the department

The lab of Jacqueline Jacobs at the division of Oncogenomics is looking for a talented and enthusiastic postdoc to investigate the molecular mechanisms by which mammalian cells respond to telomere maintenance problems or to DNA damage.

Our fundamental aim is to understand the processes that act to safeguard genome integrity but that, when working inappropriately, cause cells to die, get derailed and cancerous, or become dysfunctional and contribute to aging. We aim to identify new factors and molecular mechanisms that are critical in telomere maintenance, DNA damage responses and DNA repair. Our projects are in large part driven by functional genetic screening in mammalian cells, followed by in-depth mechanistic studies of selected screen hits and complemented with candidate-approaches.

Your profile

An ambitious postdoc, capable of independent thinking, with strong commitment and a solid background in molecular biology and cell biology. We expect you to be highly self-motivated, creative, able to work in a team and to have published (or about to publish) in a peer-reviewed journal. Previous experience in the DNA damage field, telomeres, or functional genetic screening in mammalian cells is desirable but not an absolute requirement.

Your career opportunities and terms of employment

You will join an international research team in a stimulating and interactive research environment. You will have access to state-of-the-art equipment and facilities with dedicated support staff and you will have the opportunity to follow high-quality courses offered by the NKI postdoc career development program.
Your temporary employment will be for a period of 2 years with a possible extension to 4 years. We offer a competitive salary (including possibilities for additional tax-reduction) and housing facilities in the vicinity of the institute. The gross salary per month will be from € 3097 to € 3774 according to the FWG-function group 55, depending on education and previous experience.
The terms of employment will be in accordance with the CAO Ziekenhuizen (Collective Labour Agreement for Hospitals).
For further information please visit our home page ( or contact Dr. Jacqueline Jacobs at tel. +31 20 5121784 or e-mail:
When applying please include a list of your publications and the contact details of 2 referees.
Selected reading:
Boersma V, Moatti N, Segura-Bayona S, Peuscher MH, van der Torre J, Wevers BA, Orthwein A, Durocher D and Jacobs JJL. MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end-resection. Nature 521, 537-540 (2015).

Acquisition for this vacancy is not appreciated.


How to apply

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