EU-LIFE

Building and promoting Excellence in Life Sciences in Europe
Building and promoting Excellence in Life Sciences in Europe

Postdocs - Chromatin Genomics

Description

Your function within the department

In the lab of Bas van Steensel, Netherlands Cancer Institute
 
The laboratory
We study gene regulation and its links to chromatin and the spatial organization of the genome. We develop and apply new genomics technologies for this purpose. For example, we have developed powerful new high-throughput reporter assays to study the effects of chromatin on gene expression [1] and a method to map the spatial organization of the entire genome in single cells [2]. The lab is an interdisciplinary team consisting of ~12 PhD students, postdocs, technicians and bioinformaticians.
 
The projects

  • Enhancers can selectively interact with specific promoters in the genome, often over long distances. How do they "choose" their target promoters [3]? We will use new powerful genome deconstruction methods to unravel the mechanisms that drive this specificity in mammalian cells.
  • How are lamina-associated domains positioned at the nuclear periphery, and what is the impact on gene regulation? We will use our unique single-cell DamID technology and genome perturbation methods to elucidate the underlying mechanisms in mammalian cells.

Your profile

We are looking for 2 postdocs who enjoy working with cutting-edge deep-sequencing based technologies. Good communication skills are essential. Expertise in chromatin biology, genomics methods and/or basic bioinformatics are preferred.

Your career opportunities and terms of employment

The temporary employment will be for a period of up to 4 years. The gross salary per month will be from € 3.363 to € 3.774 maximum, according to the FWG function group 55 and is dependent on experience.
 
For information
Please contact Bas van Steensel, telephone +31-20-5122040, or visit our lab website at http://research.nki.nl/vansteensellab.
 

Selected publications:

  1. Akhtar W, et al (2013). Chromatin position effects assayed by thousands of reporters integrated in parallel. Cell 154:914-927.
  2. Kind J, et al. (2015). Genome-wide maps of nuclear lamina interactions in single human cells. Cell 163:134-147.
  3. van Arensbergen J, van Steensel B, Bussemaker HJ (2014). In search of the determinants of enhancer-promoter interaction specificity. Trends Cell Biol. 24:695-702.

Interested?

How to apply

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