Postdoctoral Research Scientist (Lymphocyte Gene Regulation)
We wish to recruit a highly motivated Postdoctoral Research Scientist to investigate the transcriptional and epigenetic mechanisms by which T cell receptor-driven functional programmes are controlled. The work will be an important step towards understanding how immune function is controlled during immune responses to infection and cancer.
The laboratory utilises mouse genetics, cellular immunology and molecular biology to understand molecular mechanisms of immunity, peripheral tolerance and immunosuppression [Refs 1-6]. T cells produce divergent functional outcomes in response to T cell receptor signalling dependent upon their environment and differentiation state. This position will focus on gaining a mechanistic understanding of the transcriptional and epigenetic processes involved in controlling the divergent T cell receptor-driven functional programmes of distinct CD4+ and CD8+ T cell types. Candidates should have a PhD or MD/PhD and a good understanding of immunology and molecular biology.
The successful applicant will join the laboratory of Dr Rahul Roychoudhuri within the Lymphocyte Signalling and Development ISP at The Babraham Institute. The applicant will gain exposure to cutting-edge experimental approaches in cellular and molecular immunology including conditional mouse genetics, molecular biology and high throughput RNA- and DNA-sequencing-based techniques. The applicant will also have the opportunity to utilise platforms for high-throughput CRISPR/Cas9-based mutagenesis screens recently developed in the laboratory which will enable high-multiplicity deconvolution of gene regulatory networks. The applicant will benefit from the collaborative and collegial environment of the laboratory, the Institute and the wider research community present in Cambridge.
For more information on the work of the Roychoudhuri group, please visit: https://www.babraham.ac.uk/our-research/lymphocyte/rahul-roychoudhuri. For informal enquiries, or to find out specific details about available projects in the laboratory, please email firstname.lastname@example.org.
The position is available for two years in the first instance.
Starting salary is £30,751 per annum to £34,166 per annum depending on experience.
Full details of the position can be found here.
On applying please quote reference LGR-RR-LTC.
Closing date for completed applications is Thursday, 3 May 2018.
NO AGENCIES PLEASE
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