Postdoctoral Research Scientist (Molecular mechanisms of tumour immunity and immunosuppression)
We wish to recruit a highly motivated Postdoctoral Research Scientist to investigate molecular mechanisms by which T cell immunity is suppressed in cancer. The work will contribute to our general understanding of molecular mechanisms of tolerance and immunosuppression and pave the way for therapies that work by modulating T cell responses during inflammation and cancer.
CD4+ and CD8+ effector T cells promote immune activation and drive clearance of infections and cancer. However, effector T cells can also promote autoimmune and allergic inflammation, a deleterious activity which is restrained by a diverse set of peripheral tolerance mechanisms. Whereas mechanisms of peripheral tolerance play a beneficial role in preventing inflammation, they also powerfully suppress immune responses against cancer in a process known as immunosuppression . The laboratory utilises mouse genetics, cellular immunology and molecular biology to understand mechanisms of peripheral tolerance and immunosuppression [2-7]. This position will focus on gaining a mechanistic understanding of processes involved in tumour immunosuppression. Candidates should have a PhD or MD/PhD, a good understanding of immunology and technical experience in molecular biology and cellular immunology.
The successful applicant will join the laboratory of Dr Rahul Roychoudhuri within the Lymphocyte Signalling and Development ISP at The Babraham Institute. The applicant will have access to cutting-edge experimental approaches including conditional mouse genetic systems, mouse genetic models of cancer, flow cytometry, molecular biology and RNA- and DNA-sequencing-based techniques. The applicant will also be able to utilise platforms for high-throughput CRISPR/Cas9-based genetic screens recently developed in the laboratory. The applicant will also benefit from the Babraham Institute’s world-class expertise in molecular immunology, epigenetics, protein and lipid biochemistry, cell signalling and cell biology and from the collaborative and collegial environment of the laboratory and broader Institute.
For more information on the work of the Roychoudhuri group, please visit: https://www.babraham.ac.uk/our-research/lymphocyte/rahul-roychoudhuri. For informal enquiries, or to find out specific details about available projects in the laboratory, please email firstname.lastname@example.org.
Starting salary is £30,751 per annum to £34,166 per annum depending on experience.
The position is available for two years in the first instance.
Full details of the position can be found here.
On applying please quote reference DGY-RR-LTC.
Closing date for completed applications is Thursday, 3 May 2018
NO AGENCIES PLEASE
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