EU-LIFE

Building and promoting Excellence in Life Sciences in Europe
Building and promoting Excellence in Life Sciences in Europe

Postdoctoral Research Scientist (Molecular mechanisms of tumour immunity and immunosuppression)

Description

We wish to recruit a highly motivated Postdoctoral Research Scientist to investigate molecular mechanisms by which T cell immunity is suppressed in cancer. The work will contribute to our general understanding of molecular mechanisms of tolerance and immunosuppression and pave the way for therapies that work by modulating T cell responses during inflammation and cancer.
 
CD4+ and CD8+ effector T cells promote immune activation and drive clearance of infections and cancer. However, effector T cells can also promote autoimmune and allergic inflammation, a deleterious activity which is restrained by a diverse set of peripheral tolerance mechanisms. Whereas mechanisms of peripheral tolerance play a beneficial role in preventing inflammation, they also powerfully suppress immune responses against cancer in a process known as immunosuppression [1]. The laboratory utilises mouse genetics, cellular immunology and molecular biology to understand mechanisms of peripheral tolerance and immunosuppression [2-7]. This position will focus on gaining a mechanistic understanding of processes involved in tumour immunosuppression. Candidates should have a PhD or MD/PhD, a good understanding of immunology and technical experience in molecular biology and cellular immunology.
The successful applicant will join the laboratory of Dr Rahul Roychoudhuri within the Lymphocyte Signalling and Development ISP at The Babraham Institute. The applicant will have access to cutting-edge experimental approaches including conditional mouse genetic systems, mouse genetic models of cancer, flow cytometry, molecular biology and RNA- and DNA-sequencing-based techniques. The applicant will also be able to utilise platforms for high-throughput CRISPR/Cas9-based genetic screens recently developed in the laboratory. The applicant will also benefit from the Babraham Institute’s world-class expertise in molecular immunology, epigenetics, protein and lipid biochemistry, cell signalling and cell biology and from the collaborative and collegial environment of the laboratory and broader Institute.
 
For more information on the work of the Roychoudhuri group, please visit: https://www.babraham.ac.uk/our-research/lymphocyte/rahul-roychoudhuri. For informal enquiries, or to find out specific details about available projects in the laboratory, please email rahul.roychoudhuri@babraham.ac.uk.

Starting salary is £30,751 per annum to £34,166 per annum depending on experience.
 
The position is available for two years in the first instance.
 
Full details of the position can be found here.
 
On applying please quote reference DGY-RR-LTC.
 
Closing date for completed applications is Thursday, 3 May 2018
 
NO AGENCIES PLEASE
 
The Babraham Institute holds a silver Athena SWAN award and is committed to promoting and developing a culture of excellence, diversity and mutual respect that supports the Institute’s ambitions and attracts highly motivated and talented people.
 
The Babraham Institute is a Disability Confident Employer and has a positive approach to employing disabled people.
 
The Babraham Institute receives strategic funding from the Biotechnology and Biological Sciences Research Council and is an Equal Opportunities Employer.

 
 


As you will see, the person specification states the minimum knowledge, experience and skills required by the Institute to enable the person to do this job. When you are completing the application form you should remember that it will be used in assessing who should be shortlisted and invited for an interview. Please refer to the person specification and state your reasons for applying for the post, relating your knowledge, experience and skills gained either through work or voluntary activities, to the requirements of the job. If you wish to attach a c.v. or supplementary information please feel free to do so. To ensure no conflict of interest may arise, please indicate on your completed application whether or not you are related to any current member of Institute staff.

The Babraham Institute aims to promote equality of opportunity for all with the right mix of talent, skills and potential. The Babraham Institute welcomes applications from diverse candidates. Criminal records will be taken into account for recruitment purposes only when the conviction is relevant. Unless the nature of the work demands it, you will not be asked to disclose convictions which are 'spent' under the Rehabilitation of Offenders Act 1974. Having an 'unspent' conviction will not necessarily bar you from employment. This will depend on the circumstances and background to your offence(s).

However, all vacancies within our Nursery are exempt from the Rehabilitation of Offenders Act 1974 because the positions entail working with children.

The Babraham Institute is continually trying to find ways to reduce its administrative costs, as such we have made the decision not to write to those candidates who have not been shortlisted for interview. Therefore, please be aware that if you have not heard from us within one month of the closing date, you can assume that your application has been unsuccessful.

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