EU-LIFE

Building and promoting Excellence in Life Sciences in Europe
Building and promoting Excellence in Life Sciences in Europe

Course

24 Nov 27 Nov 2015
Oeiras Portugal

Course description

The sequence of a genome alone does not carry enough information to fully understand how genomic processes are carried out in the cell nucleus; to achieve this, the knowledge of the three-dimensional (3D) architecture of a genome is necessary. Advances in genomic technologies and the development of new analytical methods, such as 3C-based methods, have allowed getting insights at unprecedented resolution into how the genome is organized. Recently, it has been shown that chromatin is organized in Topologically Associating Domains (TADs), large interaction domains that appear to be conserved among different cell types. In this course, participants will learn to use TADbit, a software for the analysis and modeling of Hi-C data.

The course will cover all the aspect of modeling with Hi-C data:
Generation of Hi-C contact matrices from raw data (that is, Hi-C specific quality check of the reads, mapping, filtering and normalization)
Analysis of Hi-C matrices (Hi-C map visualization, TAD identification, experiment comparison, and TAD selection)
3D modeling and analysis of TADs
The 3D module of TADbit is based on a computational module of the Integrative Modeling Platform (IMP, http://www.integrativemodeling.org) that uses chromosome conformation capture data to determine the 3D architecture of genomic domains and entire genomes at unprecedented resolutions.
Participants can bring-in specific biological questions and/or their on data to work on during the course.
At the end of the course, participants will be familiar with the TADbit software, enabling them to fully analyze and model Hi-C data.
Target Audience

The course is oriented to experimental researchers and bioinformaticians at the graduate and post-graduate levels. The last edition of this course was attended by people with different backgrounds and interested in the genome organization.
Moreover, Hi-C data have recently been used in metagenomics studies to accurately cluster metagenome assembly contigs into groups that contain nearly complete genomes of each species.
It is likely that the participants to this course aim at getting involved in generating Hi-C data for chromosome structure determination or that they just want to be able to correctly interpret and analyze publicly available data.

http://gtpb.igc.gulbenkian.pt/bicourses/CSDM15

IMPORTANT DATES for this Course:
Deadline for applications: November 15th 2015
Notification of acceptance within 72 hours of application (working days count)
Course date: November 24th to November 27th 2015

CSDM15 Course duration: 4 days CSDM15 Course Fee: Euro 360.00

30 Nov 3 Dec 2015
Oeiras Portugal

Course description

Implementation of cancer genomics into the clinic is becoming a reality. Personalised medicine or "Precision medicine" as some authors refer to it, uses molecular data from a specific patient to guide clinical decisions such as prevention, diagnosis and treatment. This will revolutionise healthcare and will play a dominant role in the future of cancer therapy. Bioinformatics analyses are essential to identify patients who will benefit from treatment based on their molecular profile, and to tailor chemotherapeutic regimens accordingly.

The aim of this course is to present a complete computational pipeline for the analysis and interpretation of Next-Generation Sequencing (NGS) data, such as exome sequencing or targeted panels that are commonly used in the clinic.

We will address the implementation of large-scale genomic sequencing in clinical practice and recently developed computational strategies for the analysis of NGS data. Particular emphasis will be placed on the interpretation of results, selection of biomarkers for drug responses and affording opportunities to match therapies with the characteristics of individual patient tumours.

Case studies will be used to illustrate the principles of how genetics has influenced the refinement of diagnoses and personalised treatment of cancer disease.

http://gtpb.igc.gulbenkian.pt/bicourses/TBHD15

LECTURES:
Fátima AlSharhour,
Javier Perales and
Elena Piñeiro.

IMPORTANT DATES for this Course:
Deadline for applications: Nov 16th 2015
Latest notification of acceptance: Nov 17th 2015
Course dates: Nov 30th 2015 to Dec 3rd 2015

TBHD15 Course duration: 4 days TBHD15 Course Fee: Euro 360.00