Building and promoting Excellence in Life Sciences in Europe
Building and promoting Excellence in Life Sciences in Europe

Bioinformatician - Deep mutational scanning


The Institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG shares principles of an interdisciplinary, motivated and creative scientific team that is supported by high-end and innovative technologies and a flexible and efficient administration.

In November 2013, the Centre for Genomic Regulation (CRG) received the 'HR Excellence in Research' logo from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

Please, check out our Recruitment Policy

The role
A Bioinformatician position to develop a computational pipeline for deep mutational scanning experiments

About the team/ lab/ department

The Genetic Systems lab which is part of the CRG Systems Biology program,has recently demonstrated that it is possible to determine the 3D structures of proteins by quantifying the effects of a very large number of mutations in parallel using selection and sequencing. This genetic approach to structure determination relies on the quantification of unexpected interactions (genetic interactions or epistasis) between mutations and provides a new experimental strategy for structure determination, with the exciting potential to reveal the in vivo structures of molecules (Schmiedel + Lehner, Nature Genetics, in press,

The lab (currently ~12 members) is highly collaborative with a flat structure and works with many different systems and approaches, including model organisms and human genetic data, choosing the system and approach for the question at hand. This creates a highly inter-disciplinary environment with many members of the lab using both experimental and computational approaches. All lab members lead their own projects. To date, 12 alumni from the lab have started their own labs, including in some of the most prestigious institutes in Europe and elsewhere.

Whom would we like to hire?

We are looking for a bionformatician to join the lab to take on one of these exciting projects involving deep mutagenesis.

Professional experience

Must Have

  • You hold a hold a PhD in computational biology,  University Degree and a Masters Degree in a field of life sciences, engineering and/or physics within the European Higher Education System (minimum 300 ECTS)

Education and training

  • You have substantial research experience in both molecular and computational biology


  • You are fluent in English

The Offer

  • Contract duration: Till December 19, 2019
  • Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
  • Target Start date: As soon as possible.

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities.

We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, race, religion or sexual orientation.

The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.

Application Procedure
All applications must include:

  1. A motivation letter addressed to Dr Lehner.
  2. A complete CV including contact details.
  3. Contact details of two referees.

All applications must be addressed to Dr. Lehner and be submitted online through the Applybutton below

Deadline: Please submit your application by July 22nd ,2019

Host Institute