EU-LIFE

Building and promoting Excellence in Life Sciences in Europe
Building and promoting Excellence in Life Sciences in Europe

Engineer/Post-doctoral positions

Description

Engineer/Post-doctoral positions

Fachinetti group, Institut Curie, Paris

Elucidating the impact of centromeric DNA in cell division and health

The centromere is a complex structure made of repetitive DNA and proteins necessary for cell division. The preservation of centromere position and function is a crucial challenge for cells in order to maintain a correct  chromosome  karyotype  following  cell  division. Despite  recent  progress  in  understanding  the assembly  and  the  regulation  of  centromeres  at  the  protein  level,  the  underlying  centromeric  DNA sequences remain largely unexplored.
The Fachinetti laboratory is recruiting two engineers or post-doctoral  researchers to  discover  the  role  of repetitive DNA and its DNA  sequence specific binding protein in  centromere  architecture,  maintenance and function thus providing novel information on how centromeres are formed de novo in humans.
Highly  motivated  individuals  interested  in  the  fundamental  mechanisms  of  chromosome  dynamics  are encouraged  to  apply. The  successful  applicant  must  have  strong  expertise  in:  1)biochemistry (e.g. protein expression  in  bacteria, insect and  mammalian cells  systems, purification,  chromatography, characterization, interaction  assays, etc) OR 2) Molecular biology & single molecule technologies to study DNA architecture. Fluency in English (written and oral) is required. For the post-doctoral position, the successful applicant must have, or be in the process of completing, a doctorate in a relevant research area  and  a  primary  research  paper  in  a  peer-reviewed  journal. The  Institut  Curie  represents  an  excellent location to perform multidisciplinary research supported by a strong network of technological platforms.
Applicants    should    send    their    CV,    details    of    two/three    referees and a    cover letter to

.
Funding  for  the engineer/post-doctoral  researcher is  supported  by ANR grants for one  or two years. Application deadline is April 2019. Latest starting date June 2019.
Our website: https://science.institut-curie.org/team-fachinetti
Most relevant 10 publications from the last 5 years
1. Barra, V. et al, and Fachinetti, D.(2019). Nature Communications
2. Barra, V. and Fachinetti, D.(2018). Nature Communications, 9(1):4340.
3. Hoffmann, SandFachinetti, D(2018). Methods Mol Biol. 2018;1832:223-241.
4. Dumont, M and Fachinetti, D(2017). Prog Mol Subcell Biol;56:305-336
5. Sathyan, K., Fachinetti, D., Foltz, D. (2017). Nature Communications.8:14678. 6. Nechemia-Arbely, Y., Fachinetti, D., et al (2017). Journal of Cell Biology. 216(3):607-621.
7. Fachinetti, D.et al(2017). Developmental Cell,40, 104-113.
8. Hoffmann, S., Dumont, M., et al., and Fachinetti, D.#(2016). Cell Reports 17, 2394–2404.
9. Fachinetti, D.et al(2015). Developmental Cell, 33, 314–327.
10. Fachinetti, D., et al(2013). Nat Cell Biol, 15, 1056-66.

 

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