Fachinetti group, Institut Curie, Paris
Elucidating the impact of centromeric DNA in cell division and health
The centromere is a complex structure made of repetitive DNA and proteins necessary for cell division. The preservation of centromere position and function is a crucial challenge for cells in order to maintain a correct chromosome karyotype following cell division. Despite recent progress in understanding the assembly and the regulation of centromeres at the protein level, the underlying centromeric DNA sequences remain largely unexplored.
The Fachinetti laboratory is recruiting two engineers or post-doctoral researchers to discover the role of repetitive DNA and its DNA sequence specific binding protein in centromere architecture, maintenance and function thus providing novel information on how centromeres are formed de novo in humans.
Highly motivated individuals interested in the fundamental mechanisms of chromosome dynamics are encouraged to apply. The successful applicant must have strong expertise in: 1)biochemistry (e.g. protein expression in bacteria, insect and mammalian cells systems, purification, chromatography, characterization, interaction assays, etc) OR 2) Molecular biology & single molecule technologies to study DNA architecture. Fluency in English (written and oral) is required. For the post-doctoral position, the successful applicant must have, or be in the process of completing, a doctorate in a relevant research area and a primary research paper in a peer-reviewed journal. The Institut Curie represents an excellent location to perform multidisciplinary research supported by a strong network of technological platforms.
Applicants should send their CV, details of two/three referees and a cover letter to
Funding for the engineer/post-doctoral researcher is supported by ANR grants for one or two years. Application deadline is April 2019. Latest starting date June 2019.
Our website: https://science.institut-curie.org/team-fachinetti
Most relevant 10 publications from the last 5 years
1. Barra, V. et al, and Fachinetti, D.(2019). Nature Communications
2. Barra, V. and Fachinetti, D.(2018). Nature Communications, 9(1):4340.
3. Hoffmann, SandFachinetti, D(2018). Methods Mol Biol. 2018;1832:223-241.
4. Dumont, M and Fachinetti, D(2017). Prog Mol Subcell Biol;56:305-336
5. Sathyan, K., Fachinetti, D., Foltz, D. (2017). Nature Communications.8:14678. 6. Nechemia-Arbely, Y., Fachinetti, D., et al (2017). Journal of Cell Biology. 216(3):607-621.
7. Fachinetti, D.et al(2017). Developmental Cell,40, 104-113.
8. Hoffmann, S., Dumont, M., et al., and Fachinetti, D.#(2016). Cell Reports 17, 2394–2404.
9. Fachinetti, D.et al(2015). Developmental Cell, 33, 314–327.
10. Fachinetti, D., et al(2013). Nat Cell Biol, 15, 1056-66.