EU-LIFE

Building and promoting Excellence in Life Sciences in Europe
Building and promoting Excellence in Life Sciences in Europe

PHD/Postdoc Chromosome Biology

Description

Your function within the department

We are looking for a PhD/Postdoc  student to join the Rowland laboratory. Research in our lab is driven by fundamental questions that touch upon the essence of chromosome biology and its links to the cell cycle and gene regulation. How does cohesin lock together the sister chromatids in S phase? How does cohesin structure chromosomes in interphase? And how does condensin drive chromosome compaction in mitosis? We aim to address such questions using a combination of genetics, genomics, biochemistry and imaging, using both human cells and budding yeast as our model systems.

Your profile

We are seeking for a highly ambitious PhD studentship or Postdoc with a passion for chromosome biology. A background and or degree in molecular biology is essential, and experience with microscopy, genetics, biochemistry and/or bioinformatics is appreciated.

Your career opportunities and terms of employment

You will join a dynamic international research team, and will collaborate with scientists with expertise in different disciplines. You will have the opportunity to follow high-quality courses offered by the OOA oncology graduate school throughout your PhD. Your temporary employment will be for a period of at least four years. The gross salary for per month for our PHD will be from € 2665  to €3008 according to the standard PhD scales. For our Postdoc position this would range from € 3215 to €3917. The terms of employment will be in accordance with the CAO Ziekenhuizen (Collective Labour Agreement for Hospitals).

For further information about the position, please contact Dr. Benjamin Rowland.
E-mail: b.rowland@nki.nl
Website: http://research.nki.nl/rowlandlab
Applications can be submitted through the link below, and should include your resume, a motivational letter, and the contact information of your references.

Selected reading
Haarhuis, J.H.I., van der Weide, R.H., Blomen, V.A., Yáñez-Cuna, J.O., Amendola, M., van Ruiten, M.S., Krijger, P.H.L., Teunissen, H., Medema, R.H., van Steensel, B., Brummelkamp, T.R., de Wit, E., and Rowland, B.D. (2017) The cohesin release factor WAPL restricts chromatin loop extension. Cell 169 (693-707)
Elbatsh, A.M.O., Haarhuis, J.H.I., Petela, N., Chapard, C., Fish, A., Celie, P.H., Stadnik, M., Ristic, D., Wyman, C., Medema, R.H., Nasmyth, K., and Rowland, B.D. (2016) Cohesin releases DNA through asymmetric ATPase-driven ring opening. Molecular Cell 61 (575-588)
Haarhuis, J.H.I., Elbatsh, A.M.O., and Rowland, B.D. (2014) Cohesin and its regulation: On the logic of X-shaped chromosomes. Developmental Cell 31 (7-18)

Acquisition for this vacancy is not appreciated.

Interested?

How to apply

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