EU-LIFE

Building and promoting Excellence in Life Sciences in Europe
Building and promoting Excellence in Life Sciences in Europe

Post-doctoral fellow or PhD student in Computational Biology

Description

Your function within the department

The research groups of Dr Marleen Kok, Pia Kvistborg and Lodewyk Wessels, are looking for a motivated and talented Computational Biologist to join their teams at the Netherlands Cancer Institute (NKI).
The translational breast cancer immunology group of Dr Marleen Kok focuses on dissecting breast cancer-immune interactions, to optimize immunotherapy for breast cancer patients using novel combination treatments in clinical trials and the discovery of predictive biomarkers. Using exome, TCR and whole transcriptome sequencing as well as immunofluorescence of the tumor microenvironment, we are providing better understanding on how immune checkpoint blockade affects the breast tumor microenvironment. In parallel, systemic immune response characteristics are studied. You will be a key player in a translational research team with clinicians, cancer researchers and immunologists.
 
The T cell immunology group of Dr Pia Kvistborg focuses on understanding the state of tumor-specific T cells in cancer. We are studying T cells using high-dimensional (>20-30) flow cytometry and gene expression profiles both on population and single cell level. To get a comprehensive view of the immune status of individual patients as well as on patient cohort level, we are combining the information about T cell states with information from tumor RNA and exome sequencing. For this work you will be instrumental in developing computational pipelines for data analysis.
 
The Computational cancer biology group of Prof dr Lodewyk Wessels is focused on quantifying and understanding treatment response in model systems and patients. To this end we develop bespoke and novel computational methods focusing on data integration and tailored to new technologies. We actively collaborate with many research groups in the NKI and strongly believe in the power of 'team science'.

Your profile

You are an ambitious, creative computational biologist, with a strong commitment to translational research. Candidates should hold a degree or have expertise in bioinformatics, computer science or a related discipline, have experience in statistics and/or machine learning and be proficient in bioinformatics programming languages (e.g. R, Python). We expect candidates to be team-players with strong communication skills. General background knowledge in biology and immunology is preferable, and experience with projects involving genomics to identifying candidate targets and biomarkers is a plus.

Your career opportunities and terms of employment

You will join a dynamic international research group. You will collaborate with scientists and clinicians with expertise in different disciplines. You will have the opportunity to follow high-quality courses offered by the NKI PhD program and postdoc career development program. Your temporary employment will be for a period of 2-4 years. The gross salary per month will be € 2.665,- to € 3.282,- for PhD students.
For post-doctoral fellows from € 3215,- to €3917,- according to the FWG-function group 55, and depends on previous experience. The terms of employment will be in accordance with the CAO Ziekenhuizen (Collective Labour Agreement for Hospitals). Amsterdam is a very livable city with many cultural amenities. The institute is located within a 20 minute tram or bicycle ride from the center of Amsterdam and within 20 minutes from Schiphol airport by car, bus or bicycle.

Interested?

For further information please visit our home pages
Kvistborg group: https://www.nki.nl/people/kvistborg-pia/
Computational Cancer Biology: ccb.nki.nl or contact
Marleen Kok, or Pia Kvistborg, or Lodewyk Wessels,

How to apply

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