Postdoctoral position: Genetic perturbation of molecular networks
A postdoctoral fellow position is available in the group of Guillaume Diss at the Friedrich Miescher Institute for Biomedical Research (FMI) in Basel. The aim of the laboratory is to study how genetic variation leads to phenotypic variation, i.e. through which molecular mechanisms can mutations affect the phenotype and lead to diseases or functional innovations. This requires a better understanding of i) how mutations perturb the organization of molecular networks, which form the interface between the genotype and the phenotype, and ii) how the effect of a mutation depends upon additional genetic variation present between individuals, a phenomenon known as epistasis or genetic interactions.
The research project will combine quantitative genetics, biochemistry and systems biology approaches together with modeling and computational biology to develop quantitative and mechanistic models of mutation effects. We will use large-scale genetic perturbation screens and measure the effects of hundreds of thousands of mutations at different levels of organization, from single genes (including measurements of expression, protein stability, enzymatic activity) to molecular interactions (protein-protein, protein-nucleic acids), network architecture and fitness. We will use the data we generate to study how the effects of mutations propagate through non-linear relationships linking the different levels of organization between the genotype and the phenotype, perturb the organization of molecular networks and modify the phenotype in non-additive ways.
The successful candidate should have recently completed a PhD in yeast biology with strong skills in yeast genetics and molecular biology and have deep interests in understanding biological complexity and its evolution. Good knowledge of biophysics, experience in statistical analysis of large-scale datasets and/or proficiency in R and python/perl are a plus.
The FMI – affiliated with the University of Basel and the Novartis Institutes for Biomedical Research – is a world-class biomedical research institute dedicated to understanding the molecular mechanisms of health and disease. The FMI is also committed to the training of young scientists. It is based in the vibrant city of Basel, Switzerland, which offers an exceptional scientific and cultural environment. The position includes access to FMI state-of-the-art research facilities and a competitive salary.