21st Course on Epigenetics

Towards a quantitative understanding of nuclear dynamics during development and diseases

The aim of this course is to provide an overview of epigenetic mechanisms and their links to gene expression and chromatin dynamics, in different systems. The diverse functions of the nucleus involving the genome and its organization will be discussed with an emphasis on technological limits and the new experimental approaches being developed today. Links between the disruption of nuclear functions and the development of human pathologies will be discussed. This year emphasis will be on the physiological and pathological aspects of epigenetics in relation with metabolism and maintenance of cell identity.

The success of the course relies on the contributions of participants who are expected to be proactive and to participate in all of the events organized, including Poster sessions, Journal Club, and the different workshops (see personal Work & program for more information).

A special session will be devoted to 1-2 course alumni who have developed successful careers in the field of Epigenetics.

The main themes that will be treated are:

Epigenetics and Chromatin Dynamics
Imaging the Nucleus and its functions
Silencing, transcriptional landscapes and genomics
Memory of transcriptional states, stem cells and reprogramming
Epigenetics: quantitative approaches and theoretical models maintenance of (Epi)genome integrity
Epigenetics and Cancer